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Entrapment efficiency for the silk fibroin nanoparticles had been discovered to be 85% for coated and uncoated nanoparticles. Nanoparticles with typical diameter less than 150 nm having negative cost were discovered to show no poisoning of its very own. The pro-inflammatory reaction of nanoparticles was seen by identifying the cytokines level, such as TNF-α and IL-1β. Suffered drug release structure through the nanoparticles with much better cytotoxicty when com