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AuHPCN-222 showed selective and better electrocatalytic activity toward ED than GCE. The differential pulse voltammetric measurements by the fabricated sensor showed two linear determination ranges for ED; those are 0.01-1 and 1-220 μM. The measured limit of detection (m-LOD) was found to be 0.5 nM with the highest sensitivity of 2.2 μA μM cm-2. The analytical performances for the detection of ED in human urine and serum samples were done with reasonable recoveries (98%-103%) using the standard addition method. Also, the sensor showed be