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While an increasing human anatomy of researches centered on L. reuteri, you can still find many unknowns regarding its curative effects, medical security, and exact systems. In this review, we initially interpreted the basic features of L. reuteri and its associated metabolites. Then, we comprehensively summarized its features in different abdominal conditions, including inflammatory bowel disease, colorectal cancer tumors, infection-associated bowel diseases, and pediatric abdominal disorders. We also highligh