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Rational design and fabrication of graphene nanoarchitectures with multifunctionality and multidimensionality remains quite a challenge. Here, we present a synthetic sequence, based on the combination of two advanced patterned-functionalization principles, namely, laser-writing and poly(methyl methacrylate) (PMMA)-assisted lithographic processes, leading to unprecedented covalently doped graphene superlattices. Spatially resolved supratopic- and Janus-binding were periodically weaved on the graphene sheet, leading to four different typ