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12). The effectiveness based on patient self-assessment after treatment in the TAC + 5-FU group was also superior than the TAC group (P  less then  0.05). The overall complication rate in the TAC + 5-FU group was lower than the TAC group (P  less then  0.05). CONCLUSIONS Combination of TAC with 5-FU is more effective and safer than TAC alone therapy in the treatment of keloids and hypertrophic scars. Data on keloids alone or hypertrophic scars alone are, however, limited. A better understanding of effective after intralesional combinat