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0001). Two C-terminal brevican peptides strongly correlated with unfavourable outcome of TBI patients (rho=0.85-0.93, p≤0.001). The decreased CSF concentrations of brevican peptides in TBI are associated with their increased degradation by ADAMTS enzymes. Furthermore, the N- and C-terminal parts of brevican are differentially regulated following TBI and may serve as outcome markers. The decreased CSF concentrations of brevican peptides in TBI are associated with their increased degradation by ADAMTS enzymes. Furthermore, the N- and C-ter