https://www.selleckchem.com/pr....oducts/FK-506-(Tacro
bLF treatment also enhanced osteoblastic differentiation and mineralized nodule formation of osteoblast-lineage cells, and repaired bone defects ex vivo. Moreover, inhibition of Smad2/3 or p38 MAPK signaling reduced the anabolic effects of bLF. Together, these results suggested that bLF is a potent osteogenic factor, which mediates its function via activation of the Smad2/3 and p38 MAPK signaling pathways. Conclusions Here, we described a novel function of bLF and its signal transduction mechanisms in osseous tissue. Along w
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