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In this article we describe and illustrate what we call a network of networks perspective and map the development of a Lead network of the Antwerp Port Authority that governs various organizations and networks in the port community before and during the COVID-19 pandemic. We find that setting a collective focus and selective integration to be crucial in the creation and reproduction of an effective system to adequately deal with a wicked problem like the COVID-19 pandemic. We use the findings on crisis management and network governance