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But, poxvirus-encoded A51R proteins block ETS-1 expression by outcompeting SSRP1 for binding to SUMOylated Spt16 when you look at the cytosol and also by tethering SUMOylated Spt16 to microtubules. Moreover, we show that A51R antagonism of FACT improves both poxvirus replication in peoples cells and viral virulence in mice. Finally, we demonstrate that REALITY also restricts unrelated RNA viruses, recommending an extensive role for REALITY in antiviral immunity. Our study reveal
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