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The frequency of cTfh within CD4 T cells was more closely associated with disease severity than the serum anti-AchR antibody titer and frequency of plasmablasts within B cells. Abnormalities of cTfh were improved after immunotherapy in parallel with clinical improvement. Alternation of cTfh is a key feature in the development of MG and may become a biomarker for disease severity and therapeutic efficacy. This study provides Class II evidence that the level of cTfh is associated with disease severity in patients with MG. This study provi
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