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081 mg/mL Fu. The inhibitory activities of RG on and platelet aggregation and thrombosis in arteriovenous shunt significantly ( 0.05) increased to approximately 66.82%, 35.42%, and 38.95%, respectively, by encapsulation within PF-NPs. For an carrageenan-induced mouse tail thrombosis model, though RG had a weaker inhibitory effect, PF-NPs reduced thrombus significantly due to the presence of PGA and Fu. PF-NPs contributed to improve the activities of RG not only by nanoencapsulation but also by antithrombotic coating materials. Ther