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Low high-density lipoprotein (HDL)-cholesterol is frequent in patients with peripheral artery disease (PAD) and also in type 2 diabetes mellitus (T2DM), the major risk factor for PAD. The transfer of cholesterol from the other lipoproteins to HDL is an important aspect of HDL metabolism and function, and may contribute to atherogenic mechanisms that lead to PAD development. The aim of this study was to investigate the status of cholesterol transfers in patients with PAD without or with T2DM. Patients with PAD ( = 19), with PAD and T2DM (