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The aim of this study was to examine the effect of various surface treatments on the bond strength of a resin luting agent and the surface roughness and surface energy of computer-aided design and computer-aided manufacturing (CAD/CAM) materials. Four types of CAD/CAM blocks (Shofu Block HC BHC; GC Cerasmart CER; VITA Enamic ENA; and Lava Ultimate LAV) were used. All blocks were randomly divided into eight groups based on the surface treatment as follows no surface treatment (C), airborne-particle abrasion (AA), hydrofluoric acid etching (HA), silan