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Given sigma receptor agonists provide neuroprotection along with other benefits such as potentiating the effects of other receptors, further development of multi-receptor targeting ligands, and or the development of multi-drug combinations to target multiple receptors may prove beneficial in the future treatment of degenerative diseases of the CNS, especially when coupled with better diagnostic techniques. Nitric oxide (NO) is a molecule with multiple functions. Several drugs involve the modulation of NO levels in their mechanism of acti

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The introduction of automated vehicles (AVs) into urban areas initially leads to mixed traffic, consisting of AVs, human drivers, and vulnerable road users. Since the AV's passenger is no longer actively involved in the driving task, there may be changes in the interaction between AVs and surrounding human road users. Therefore, it is essential for an AV to behave in a comprehensible manner in order to maintain or even enhance traffic efficiency and traffic safety. This work investigates the interaction of an AV and a simultaneously on

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2%). A total of 198 patients underwent assisted reproductive technique. This study concluded that primary infertility is the most common type among all infertile male patients who visited our center. The risk factors of male infertility include positive family history, smoking, and varicocele. This study concluded that primary infertility is the most common type among all infertile male patients who visited our center. The risk factors of male infertility include positive family history, smoking, and varicocele.

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The implications of these treatment strategies in relation to disease progression, and the prospects of their implementation in clinical practice need to be addressed.BMIz-score (BMIz) is commonly used to assess childhood obesity. Whether change in BMIz score predicts change in visceral fat remains unclear. The objective of the work was to study changes in visceral fat, cardiovascular fitness (CVF), and metabolic health over 6 months in children with stable/decreased-BMIz vs. increased-BMIz. Ninety children with obesity, re

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Knowing the underlying diseases is preferable to early diagnosis and timely initiation of antifungal therapy in order to improve survival rates. © 2020 Meidani et al.Introduction Globally, magnesium sulfate (MgSO4) has been recognized as the drug of choice for preventing and controlling fits among women with severe pre-eclampsia and eclampsia, respectively. Improper use of magnesium sulfate has been reported globally. Therefore, actionable findings for improving magnesium sulfate use are needed. This study aims at unde

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05). Conclusion NUSAP1 knockdown can inhibit the proliferation, migration and invasion, and promote the apoptosis of tumor cells through suppressing AKT/mTOR signaling pathway in lung cancer cells.Objective To verify the value of whole genomic copy number variation (WGCNV) detection and scoring system in the diagnosis and prognosis of lung adenocarcinoma. Methods Seventy-six lung adenocarcinoma specimens including ninety-one tumor samples and twenty adjacent non-tumor lung tissue samples were collected using Laser capture microdisse

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93. The experimental results were in good accordance with the ones calculated from the models. Stability of the analytes in standard solutions and processed plant samples was found acceptable up to 14 days of storage at 4 °C. The validation proved also good linearity (r 0.99995), precision (RSD less then 4 %), accuracy (96.8-99.2 %), and sensitivity (LOQs 0.14-0.61 ng; LODs 0.05-0.20 ng) of the method, and its applicability for quantification of six primary coumarins and flavan-3-ols in A. hippocastanum bark was demonstrated for re

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Despite chemotherapy being a common treatment, an increase in chemoresistance over time is unavoidable. We therefore investigated the role of miR-194-5p in regulating chordoma cell behavior and examined the downstream effectors of miR-194-5p. In this study, NSCLC cell lines A549 and H460 were cultured under hypoxic conditions for 1 week to induce drug resistance to doxorubicin (DOX). The connection between miR-194-5p and HIF-1 was revealed by reverse transcription and real-time polymerase chain reaction (RT-qPCR), western blot, and dual

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Multi-date remotely sensed images comprising Landsat TM images of 1984, 1993 and 2003 and, Landsat OLI images of 2013 were used to reconstruct long-term changes in land cover in the Swartkops River Estuary by mapping changes in vegetation distribution over a period of ~ 30 years between 1984 and 2013. These images were complemented by high-resolution near-anniversary aerial photographs that were used as ancillary sources of ground truth during supervised classification of the Landsat images. Results of our investigation point to h

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users. Assessment of seed germination is an essential task for seed researchers to measure the quality and performance of seeds. Usually, seed assessments are done manually, which is a cumbersome, time consuming and error-prone process. Classical image analyses methods are not well suited for large-scale germination experiments, because they often rely on manual adjustments of color-based thresholds. We here propose a machine learning approach using modern artificial neural networks with region proposals for accurate seed germination dete