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5 mm in 95% of squamous cell carcinomas (3.7 mm in the subgroup without neoadjuvant chemotherapy). After multivariate analysis, the factors associated with the size of MEmax were vascular invasion (P=.0002), histologic type, with a wider MEmax for adenocarcinomas in comparison with squamous cell carcinomas (P=.002), tumor size, which was inversely related with the size of MEmax (P=.024), and high blood pressure (P=.03). Macroscopic histologic tumor size was well correlated with both radiologic tumor size on a mediastinal setting computed