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The aim of this study was to evaluate the anxiety levels of the parents of infants with cleft lip and palate (CLP) before and after primary lip surgery. Forty mothers (mean ages 31.9 ± 6.16 years) and 40 fathers (mean ages 34.6 ± 5.91 years) of infants with CLP were included in this study. They were asked to answer the Amsterdam Preoperative Anxiety and Information Scale (APAIS) and Spielberger's State-Trait Anxiety Inventory (STAI) just 1 h before the primary lip surgery (T and 1 month after (T1) surgery. Student t-test an