https://www.selleckchem.com/pr....oducts/protosappanin
RESULTS We observe that computer-simulated aggregation levels mimic true disease patterns in ALS patients. Simulated patterns of involvement across cortical areas show significant overlap with the patterns of empirically impaired brain regions on later scans, at both group and individual levels. These findings are validated using an external longitudinal dataset of 30 patients. INTERPRETATION Our results are in accordance with established pathological staging systems and may have implications for patient stratification in future
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