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This study contributes to the understanding of PFAS-induced kidney damage. Further longitudinal epidemiological and toxicological studies are recommended. This study contributes to the understanding of PFAS-induced kidney damage. Further longitudinal epidemiological and toxicological studies are recommended.Nitrogen (N) plays a central role in livestock development and food production in agricultural and pastoral regions, while its flow and loss can affect environmental quality, biodiversity and human health. A comprehensive understanding of