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ns of each patient to ensure that patients feel happy and confident with the decision that they make. Research has shown that the prognosis of in-stent restenosis (ISR) lesions after drug-coated balloon (DC angioplasty can differ in relation to in-stent neointimal characteristics. However, changes in neointima characteristics after DCB have not been studied. This study sought to investigate changes in neointima characteristics after DCB for ISR. From the Yonsei Optical Coherence Tomography (OCT) registry, data on DCBs performed in pa