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In this study, we investigated the effect of age, intercourse hormones, and circadian rhythm regarding the phrase of Aβ scavengers such as apolipoprotein J, gelsolin, and transthyretin in the rat choroid plexus. Our results demonstrated that mRNA appearance and both intracellular and secreted necessary protein amounts of the studied Aβ scavengers are age-, sex-, and circadian-dependent. These information suggest that the Aβ-degradation and clearance pathways at the choroid plexus, mediated by the presence