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Early medical trials with bortezomib ended with unsatisfactory results, perhaps as this agent does not get across the blood-brain buffer. In contrast to bortezomib and other proteasome inhibitors, marizomib is a novel drug that displays strong inhibitory properties on all enzymatic subunits regarding the proteasome and, above all, crosses the blood-brain barrier, which makes it a potentially really energetic book agent against intrinsic mind tumors. While preclinical research reports have shown c