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The vasodilator contained in Vidalista 40 is tadalafil. It is specifically a phosphodiesterase type 5 inhibitor. In response to phosphodiesterase type 5 inhibition, levels of cyclic guanosine monophosphate (cGMP) increase. When blood vessels relax as a result of cGMP, more blood flows to the male genitalia, resulting in an erection. When sexually stimulated, men with erectile dysfunction are unable to effectively erect their penis.