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Prior to treatment, 5-HTT was lower in LLD patients relative to controls in cortical and limbic (amygdala) regions. Grey matter volumes were not significantly different between groups. 5-HTT occupancy was detected throughout cortical, striatal, thalamic and limbic (amygdala, hippocampus) regions. The magnitude of 5-HTT occupancy by antidepressants was 70% or greater across cortical and sub-cortical regions, consistent with the magnitude of 5-HTT occupancy observed in mid-life depressed patients. Greater regional 5-HTT occupancy correlate