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This study highlights the high burden and mortality rates of candidemia in hospitals from Parana as well as the need to enhance antifungal stewardship program in the enrolled medical centers. Two measures of cross-frequency coupling are phase-amplitude coupling (PAC) and bicoherence. The estimation of PAC with meaningful bandwidth for the high-frequency amplitude is crucial in order to avoid misinterpretations. While recommendations on the bandwidth of PAC's amplitude component exist, there is no consensus yet. Theoretical relationship