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lation aging and high smoking prevalence. These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade; however, the corresponding death toll is expected to surge, in the context of China's population aging and high smoking prevalence. These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. The COVID-19 q