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INTRODUCTION Significant number of women present with advanced-stage breast cancer in Ghana. These women usually depend on family caregivers for their multi-dimensional needs. Yet, there are gaps in research about what motivates family caregivers to assume the caring role and their experiences with caregiving within the Ghanaian context. AIM To explore and describe the caregiving motivations and experiences among family caregivers of patients living with advanced breast cancer. METHODS In-depth, semi-structured qualitative interviews we