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008) and eosinophil counts (P = 0.002) compared with subjects with no or one histologic change. Conversely, the tissue neutrophil-to-lymphocyte ratio and neutrophil count were higher in patients with no or one histologic change than in patients with two or more changes. Collectively, tissue inflammatory markers may be correlated with histologic changes in CRS. However, serum inflammatory markers have a limited ability to predict histologic changes in patients with CRS. To explore the clinicopathologic features, immunophenotype, differenti