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MCCS was then used to determine the normalized no-cost energy of each ligand therefore the residue power contribution. As a result, we found ZINC15676170, ZINC09033700, and ZINC12530139 to be the most encouraging antiviral treatments up against the 3CLpro of SARS-CoV-2.Despite well-known advantages of heterogeneous photocatalysts (availability, security, recyclability, the ease of separation from items and safety) their application in organic synthesis faces really serious challenges