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3; 95 % CI -5.36 to -1.24; p = 0.002) and decreased cerebral metabolism (pooled SMD -1.73; 95 % CI -2.7 to -0.76; p less then 0.0001). Additionally, PSEN1 was associated with increased cerebral amyloid deposition as detected by a positron emission tomography tracer (pooled SMD 4.58; 95 % CI 1.37-7.8; p = 0.0005). PSEN1 was associated with a decreased hippocampal volume in MRI markers, cerebral glucose hypometabolism, and increased cerebral amyloid deposition. These associations may indicate the potential role of neuroimaging markers fo