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Results Self-report feedback from e-visit participants indicated satisfaction with the intervention and interest in using e-visits again in the future. Nearly all e-visits resulted in prescription of a U.S. Food and Drug Administration (FDA)-approved smoking cessation medication. In general, smoking cessation outcomes favored the e-visit condition at both 1 (odds ratios [ORs] 2.10-5.39) and 3 months (ORs 1.31-4.67). Conclusions These results preliminarily indicate the feasibility, acceptability, and efficacy of this smoking cessation e