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91 to -1.42) in the liraglutide group (n = 298) and -2.81 kg (95% CI -3.43 to -2.2 in the empagliflozin group (n = 247; P 0.05). After adjusting for covariates, this effect remained nonsignificant. There was no difference in change in A1C between liraglutide (-0.83%; 95% CI -1.05% to -0.62%) and empagliflozin (-0.71%; 95% CI -0.89% to -0.53%; P 0.05). Conclusions and Relevance There was no significant difference in weight outcomes after 1 year in veterans treated with liraglutide versus empagliflozin. Because both medicatio