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The inflammation properties of the fabricated poly(acrylic acid)/cellulosic hydrogels were found to answer changes in pH, and CNC-reinforced hydrogels performed better than cellulose-reinforced hydrogels. The highly crystalline CNC provided a higher storage space modulus, thus acting as a significantly better reinforcing material for poly(acrylic acid)-based hydrogels. SEM revealed that hydrogels strengthened with the CNC nanofillers containe