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The purpose of this study was to compare the effects of exercise in cold-dry (CC, -20 °C, RH 40%) and normal conditions (NC, 20 °C, RH 60%) on salivary levels of pro-inflammatory and regulatory cytokines (IL-1RA, IL-8, and IL-5) and the airway response (FEV1 and FVC) in young healthy males. Participants (n = 11, age 23.6 ± 3.1 years) completed an incremental to maximal exercise test and two exercise sessions in an environmental chamber in random order. Saliva samples were collected, and spirometry was performed prior to the maximal exer