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The purpose of this review is to discuss the transforming growth factor beta (TGF binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.Catalytic efficiency and thermostability are the two most important characteristics of enzymes. However, it is always tough to imp
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