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INTRODUCTION Cytotoxic agents have immunomodulatory effects, providing rationale for combining atezolizumab (anti-programmed death-ligand 1 [PD-L1]) with chemotherapy. The randomized phase III IMpower131 study (NCT02367794) evaluated atezolizumab with platinum-based chemotherapy in stage IV squamous non-small cell lung cancer (NSCLC). METHODS 1021 patients were randomized 111 to receive atezolizumab+carboplatin+paclitaxel (A+CP) (n=338), atezolizumab+carboplatin+nab-paclitaxel (A+CnP) (n=343), or carboplatin+nab-paclitaxel (CnP) (n=34