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05). The smoking, FEV1/FVC values, COPD grading and mMRC scores all affected the concentration of CC16 (p less then 0.05). The decreased CC16 was an independent risk factor in the process of deterioration of lung function. The sensitivity and specificity of serum CC16 for identifying COPD reached to 65.3% and 75%. Conclusion Decreased serum concentration of CC16 correlated with the disease progression of COPD, suggesting that it can be used as an indicator contributing to the diagnosis and assessment of COPD. © 2020 Rong et al.Backg