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3%, 12/13) as opposed to localized amyloidosis (4.5%, 3/67; P less then 0.001). Repeated surgical treatment was significantly associated with laryngeal amyloidosis (35.3%, 12/34; P = 0.002) and multi-centric disease (33.3%, 10/30; P = 0.048). Airway wall thickness in patients who required repeated surgical treatment was significantly greater than in patients with stable or no recurrent disease (P = 0.016). Conclusion Knowledge of the imaging features of head and neck amyloidosis can aid the diagnosis, disease monitoring, and prediction of