https://sirtuinsignaling.com/i....ndex.php/animal-secr
Right here, we produced myeloid-specific and hepatocyte-specific DHX9 knockout mice and verified that DHX9 is essential for host opposition to RNA virus infections in vivo. By extra knockout MAVS or STAT1 in DHX9-deficient mice, we demonstrated that nucleic DHX9 plays a positive role in regulating interferon-stimulated gene (ISG) phrase downstream of type I interferon. Mechanistically, upon interferon stimulation, DHX9 is directly bound to STAT1 and recruits Pol II to your ISG promoter region to be invo
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