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05) and ulcerative colitis (p0.001) patients with active disease compared to healthy donors. PRO-C23 differentiated healthy donors from ulcerative colitis (area under the curve [AUC] 0.81, p=0.0009) and Crohn's disease (AUC 0.70, p=0.0124). PRO-C23 differentiated ulcerative colitis patients with active disease from those in remission (AUC 0.75, p=0.0219) and Crohn's disease patients with active disease from those in remission (AUC 0.68, p=0.05). PRO-C23 was elevated in rats with active colitis, and inflammatory bowel disease patients