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To address this, we created worldwide TSPO knockout (TSPO-KO) and neuronal TSPO transgenic (TSPO-Tg) mouse designs to investigate TSPO purpose in the legislation of anxiety- and depression-related behaviors utilizing elevated plus maze and required swim test paradigms. Neuroactive steroid bodily hormones had been calculated within the brain by mass spectrometry. In vivo TSPO ligand pharmacokinetics was examined using competitive dog with 18F-FE-DAA1106. Genetic TSPO de
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