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To reflect on the contribution of Florence Nightingale in the health and nursing areas based on her epistemological legacy. Reflection in which Florence Nightingale's nursing theoretical model is approached, trying to show how her family, training, social and cultural concepts influenced the formal construction of care. Florence Nightingale's vocation, profession and legacy stand out as faithful expressions of her thoughts for the professional constitution of the nurse. Responsible for the care of people with a strong humanitarian chara