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We discovered that Ankk1 is preferentially enriched in striatal D2R-expressing neurons and that Ankk1 loss in purpose within the dorsal and ventral striatum leads to alteration in learning, impulsivity, and flexibility resembling endophenotypes described in A1 companies. We additionally observed an unsuspected role of Ankk1 in striatal D2R-expressing neurons associated with ventral striatum when you look at the legislation of power homeostasis and documented differential