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Media containing more than 3 % of carbon content exerted carbon catabolite repression. The range of carbonnitogen ratios evaluated presented an increasing tendency on tacrolimus biosynthesis up to 3 % of glucose or maltose in the media, both carbon sources exerted the phenomenon of carbon catabolite repression with more than 3 % of carbon source on the media. © 2020 The Authors.Environmental ozone (O3) exposure has adverse effects on different body systems. This experimental work aimed to study the effect(s) of O3 exposure on the olfactory bulbs (OB