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Our results support the view that MED12 mutations may dysregulate the SHH signaling pathway, which may have accounted for the aberrant craniofacial morphology of our patient. Copyright © 2020 Wang, Lin, Xue, Wang, Liu, Ou, Wu, Lan, Zhang, Yuan, Luo, Wang, Xi, Sun and Chen.Genomic selection increases the rate of genetic gain in breeding programs, which results in significant cumulative improvements in commercially important traits such as disease resistance. Genomic selection currently relies on collecting genome-wide genotype data accross