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The inhibition model for EGFR kinase and the proposed procedures can be very informative in the biological testing of selected bis-indoles and may be useful for future research on effective inhibitors for the treatment of EGFR-related cancer. Communicated by Ramaswamy H. Sarma.The utmost aim of the current study is to find significance of the binding affinity in the halogen and non-halogen derivatives Br, Cl, CF3, F, CH3 and NH2 of β-d-Xylopyranose with the hinge region amino acids of ruminant-β-glycosidase. The interaction energy analys