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MS was associated with depression, anxiety, bipolar disorder, sleep disorders, schizophrenia, schizophreniform disorder, and other psychotic disorders (adjusted HR 12.464, 4.650, 6.987, 9.103, 2.552, 2.600, 2.441, and 2.574, respectively; all p 0.001). Some disease-modifying drugs were associated with a lower risk of anxiety or depression. Patients with MS were determined to have a higher risk of developing a wide range of psychiatric disorders. Patients with MS were determined to have a higher risk of developing a wide range of p