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This study aimed to investigate the expression of natural killer (NK) cell subsets in patients with acquired immune deficiency syndrome (AIDS) and deep fungal infections and the significance of such expression. A total of 829 patients with AIDS, who were treated in People's Hospital of Deyang City our hospital between January 2011 and March 2019, were enrolled in the study. They were divided into two groups those with human immunodeficiency virus (HIV) and invasive fungal infection (IFI) (HIV + IFI) (n = 39 and those with HIV and no