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Mendelian randomization analyses showed no evidence of causal association between uric acid and MetS and MetS components. Conclusions We found no causal evidence to support that increased serum uric acid is a causal risk factor for MetS or its components. Hence, there remains no strong evidence for the effeteness of undergoing urate-lowering therapy to prevent the onset of MetS or cardiovascular disease in health management. Copyright © 2020 Lu Wang et al.Background Oxidative stress is an important factor during age-related catarac