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Although several per- and polyfluoroalkyl substances (PFAS) have been banned and classified as substances of very high concern by the European Chemicals Agency, similar chemicals remain widely used compounds to date. Even though more than 4700 PFASs may occur in the environment, only 40-50 compounds are routinely determined in targeted analysis by ESI-MS using isotopically labeled standards. Nontargeted analysis using high resolution (HR) molecular mass spectrometry suffers from a lack of data mining algorithms for identification and often