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Furthermore, other high-risk and high-exposure factors may contribute to both diseases, such as alcohol and smoking abuse among parents, air pollutants PM2.5 and PM10 in the environment will also be discussed in the review. Since these environmental toxins and other harmful substances discussed in the paper have been linked to an increasing number of children with autism and ADHD in recent decades, from the medical perspective, this review will put forward certain succinct points to the aspects of minimizing relevant exposure or risks